Epileptogenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Nicole Datson
PROVIDER: E-GEOD-785 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Altered hippocampal gene expression prior to the onset of spontaneous seizures in the rat post-status epilepticus model.
Hendriksen H H Datson N A NA Ghijsen W E WE van Vliet E A EA da Silva F H FH Gorter J A JA Vreugdenhil E E
The European journal of neuroscience 20011101 9
Neuronal loss, gliosis and axonal sprouting in the hippocampal formation are characteristics of the syndrome of mesial temporal sclerosis (MTS). In the post-status epilepticus (SE) rat model of spontaneous seizures these features of the MTS syndrome can be reproduced. To get a global view of the changes in gene expression in the hippocampus we applied serial analysis of gene expression (SAGE) during the early phase of epileptogenesis (latent period), prior to the onset of the first spontaneous s ...[more]
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