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Gene expression profiling of genes differentially expressed by oral carcinoma Ca9-22 and SLPI-deficient Ca9-22 (ΔSLPI) cells

ABSTRACT: We used the myoma model in conjunction with gene expression profiling with microarray data as an efficient tool for high throughput analysis and to screen for differentially expressed genes. Our aim was to identify candidates playing an important role in SLPI and/or MMP-promoted tumor invasion by comparing oral carcinoma Ca9-22 cells, which highly express secretory leukocyte protease inhibitor (SLPI) gene, with SLPI-deficient Ca9-22 cells. In oral carcinoma Ca9-22 and SLPI-deficient Ca9-22 (ΔSLPI) samples, gene expression profiling was performed with the Affymetrix Human Genome U133 Plus 2.0 Array. Two arrays for 2 cell lines were analyzed.

ORGANISM(S): Homo sapiens

SUBMITTER: Atsushi Fukushima 

PROVIDER: E-GEOD-78501 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Human uterus myoma and gene expression profiling: A novel in vitro model for studying secretory leukocyte protease inhibitor-mediated tumor invasion.

Mikami Yoshikazu Y   Fukushima Atsushi A   Komiyama Yusuke Y   Iwase Takashi T   Tsuda Hiromasa H   Higuchi Yasuhiko Y   Hayakawa Satoshi S   Kuyama Kayo K   Komiyama Kazuo K  

Cancer letters 20160526 1

Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor that diminishes tissue destruction during inflammation. A recent report revealed high levels of SLPI expression in the oral carcinoma cell. In addition, overexpression of SLPI up-regulates metastasis in lung carcinoma cells. On the other hand, matrix metalloproteinases (MMPs) are proteinases that participate in extracellular matrix degradation. SLPI and MMPs are involved as accelerators of the tumor invasion process; ho  ...[more]

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