Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiling of genes differentially expressed by oral carcinoma Ca9-22 and SLPI-deficient Ca9-22 (ΔSLPI) cells

ABSTRACT: We used the myoma model in conjunction with gene expression profiling with microarray data as an efficient tool for high throughput analysis and to screen for differentially expressed genes. Our aim was to identify candidates playing an important role in SLPI and/or MMP-promoted tumor invasion by comparing oral carcinoma Ca9-22 cells, which highly express secretory leukocyte protease inhibitor (SLPI) gene, with SLPI-deficient Ca9-22 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE78501 | GEO | 2016/08/22

SECONDARY ACCESSION(S): PRJNA313143

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression profiling of genes differentially expressed by oral carcinoma Ca9-22 and SLPI-deficient Ca9-22 (ÎSLPI) cells

Project description:We used the myoma model in conjunction with gene expression profiling with microarray data as an efficient tool for high throughput analysis and to screen for differentially expressed genes. Our aim was to identify candidates playing an important role in SLPI and/or MMP-promoted tumor invasion by comparing oral carcinoma Ca9-22 cells, which highly express secretory leukocyte protease inhibitor (SLPI) gene, with SLPI-deficient Ca9-22 cells. In oral carcinoma Ca9-22 and SLPI-deficient Ca9-22 (ÎSLPI) samples, gene expression profiling was performed with the Affymetrix Human Genome U133 Plus 2.0 Array. Two arrays for 2 cell lines were analyzed.

2016-08-22 | E-GEOD-78501 | biostudies-arrayexpress

Comparison of gene expression profiles of colorectal adenocarcinoma HT-29 cells and oral squamous cell carcinoma Ca9-22 cells to determine SLPI-induced cell migration

Project description:we performed microarray-based gene expression profiling of HT-29, Ca9-22 and SLPI-deficient Ca9-22 cells for high-throughput analysis and for screening differentially expressed genes (DEGs)

2016-06-09 | GSE83104 | GEO

Expression data from ectopic RUNX2 over-expression in Ca9-22 cells

Project description:To examine the transcription targets of RUNX2 in OSCC cells, we preformed the Affymetrix Human Genome U133 Plus 2.0 Array with ectopic RUNX2 or empty vectors in Ca9-22 cells.

2017-02-13 | GSE74137 | GEO

Expression data from ectopic PTHLH over-expression in Ca9-22 cells

Project description:To exmaine the PTHLH stimulated genes in Ca9-22 cells, we preformed the Affymetrix Human Genome U133 Plus 2.0 Array with empty vector or PTHLH expression vector. The raw data were normalized by GeneSpring GX software and up-load with raw values.

2017-03-08 | GSE81471 | GEO

CA9 Transcriptional Profiling Experiment

Project description:MCF7 cells exposed in 0.1% hypoxia for 72h and then stained and sorted into CA9+ve and CA9-ve populations and a differential gene expression analysis was performed between the 2 cell populations.

2013-05-05 | E-MTAB-1387 | biostudies-arrayexpress

CA9 Transcriptional Profiling Experiment

Project description:CA9 Transcriptional Profiling Experiment

| PRJEB1163 | ENA

Homo sapiens

Project description:Gene expression profiling of genes differentially expressed by oral carcinoma Ca9-22 and SLPI-deficient Ca9-22 (ΔSLPI) cells

| PRJNA313143 | ENA

Gene expression profiling in Hepa1c1c7 transfected Mst1r or Slpi

Project description:To analysis Mst1r and slpi function as a tumor associated gene, we carried out overexpression analysis of Mst1r or Slpi to Hepa1c1c7 and investigated downstream genes expression by microarray.

2018-04-04 | GSE104626 | GEO

Expression profiles of human oral cancer cell lines under hypoxic conditions

Project description:A gene expression profiles of human oral squamous cell carcinoma lines, HSC-2 and Ca9-22, cultured under hypoxic conditions (1% pO2 for 24 or 48 hours) were compaired with those under normoxic conditions (21% pO2).

2014-06-01 | GSE52795 | GEO

SLPI is a novel bone-coupling factor that controls parathyroid hormone-induced bone formation

Project description:Osteoclastic bone resorption and osteoblastic bone formation/replenishment are closely coupled in bone metabolism. Anabolic parathyroid hormone (PTH), which is commonly used for treating osteoporosis, shifts the balance from osteoclastic to osteoblastic, although the mechanisms underlying this phenomenon are unclear. Here we identified a serine protease inhibitor, secretory leukocyte protease inhibitor (SLPI), as a novel coupling factor that is involved in the PTH-mediated shift to the osteoblastic phase. SLPI was highly upregulated in osteoblasts by PTH, and genetic ablation of SLPI severely impaired PTH-induced bone formation. SLPI induction in osteoblasts enhanced osteoblast differentiation intracellularly and was also secreted extracellularly, attracting neighboring osteoclasts to suppress osteoclastic function. Intravital bone imaging revealed that the PTH-mediated association between osteoblasts and osteoclasts was disrupted in the absence of SLPI. Collectively, these results demonstrate that SLPI, a previously unrecognized bone-coupling factor, mediates the communication of osteoblasts with osteoclasts to promote PTH-induced bone formation.

2021-01-17 | GSE145462 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data