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Transcription profiling of human peripheral blood CD2+ leukocytes from PATH particpants

ABSTRACT: Gene expression profiling was carried out on peripheral blood CD2+ leukocytes from 29 children with asthma. The primary research question is whether gene expression differs in individuals from high socioeconomic status environments vs low socioeconomic status environments. Experiment Overall Design: Gene expression profiling was carried out on peripheral blood CD2+ leukocytes from 29 children with asthma. The primary research question is whether gene expression differs in individuals from high socioeconomic status environments vs low socioeconomic status environments.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Cole

PROVIDER: E-GEOD-7894 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide transcriptional profiling linked to social class in asthma.

Chen E E Miller G E GE Walker H A HA Arevalo J M JM Sung C Y CY Cole S W SW

Thorax 20081110 1

<h4>Objectives</h4>Low socioeconomic status (SES) is one of the most robust social factors associated with disease morbidity, including more severe asthma in childhood. However, our understanding of the biological processes that explain this link is limited. This study tested whether the social environment could get "under the skin" to alter genomic activity in children with asthma.<h4>Design and participants</h4>Two group design of children with physician diagnosed asthma who came from low or h ...[more]

PMID: 19001005

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Differential gene expression in peripheral blood CD2+ leukocytes from PATH particpants

Project description:Gene expression profiling was carried out on peripheral blood CD2+ leukocytes from 29 children with asthma. The primary research question is whether gene expression differs in individuals from high socioeconomic status environments vs low socioeconomic status environments. Keywords: Risk prediction

2009-05-26 | GSE7894 | GEO

Transcription profiling of human peripheral blood CD14+ leukocytes from SRESS study particpants

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2008-06-20 | E-GEOD-7893 | biostudies-arrayexpress

Differential gene expression in peripheral blood CD14+ leukocytes from SRESS study particpants

2008-05-20 | GSE7893 | GEO

Gene regulation in monocytes and CD4+ T cells from low-SES vs. high-SES children with asthma

Project description:There are marked socioeconomic disparities in pediatric asthma control. To identify the molecular origins of these disparities, we performed genome-wide expression profiling of monocytes and T-helper cells isolated from pediatric asthma patients of lower- and higher socioeconomic status (SES).

2018-06-14 | GSE109455 | GEO

The Biological Residue of Low Early-Life Social Class

Project description:Research shows that children who are reared in households with low socioeconomic status are more vulnerable to heart disease, respiratory infection, and some cancers when they reach adulthood. This study conducted transcriptional profiling of PBMC in healthy adults who were low vs. high in early-life SES to explore the long-lasting genomic effects of early experience. Keywords: life stress, gene expression, inflammation, socioeconomic status

2009-03-11 | GSE15180 | GEO

The Biological Residue of Low Early-Life Social Class

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Transcription profiling of human peripheral blood leukocytes from CHASRS particpants

Project description:Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation. Experiment Overall Design: Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation.

2009-04-23 | E-GEOD-7148 | biostudies-arrayexpress

Differential gene expression in peripheral blood leukocytes from CHASRS particpants

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Project description:Socioeconomic status effect on gut microbiome.

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Difference analysis of microRNAs in peripheral blood of asthmatic children by high-throughput sequencing

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