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The Nuclear Receptor Rev-erb alpha Regulates Adipose Tissue-Specific FGF21 Signaling (ChIP-seq, eWAT)

ABSTRACT: The goal of this study is to identify the cistrome of the transcriptional repressor Rev-erb alpha in epididymal white adipose tissue. Performing Rev-erb alpha ChIP-seq on epididymal white adipose tissue from wildtype mice at 5PM when Rev-erb alpha protein level peaks in wild type (WT) mice, we were able to globally determine the genomic regions undergoing Rev-erb alpha-dependent de-repression. Examination of Rev-erb alpha binding in epididymal white adipose tissue.

ORGANISM(S): Mus musculus

SUBMITTER: Hee-Woong Lim 

PROVIDER: E-GEOD-79165 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling.

Jager Jennifer J   Wang Fenfen F   Fang Bin B   Lim Hee-Woong HW   Peed Lindsey C LC   Steger David J DJ   Won Kyoung-Jae KJ   Kharitonenkov Alexei A   Adams Andrew C AC   Lazar Mitchell A MA  

The Journal of biological chemistry 20160321 20

FGF21 is an atypical member of the FGF family that functions as a hormone to regulate carbohydrate and lipid metabolism. Here we demonstrate that the actions of FGF21 in mouse adipose tissue, but not in liver, are modulated by the nuclear receptor Rev-erbα, a potent transcriptional repressor. Interrogation of genes induced in the absence of Rev-erbα for Rev-erbα-binding sites identified βKlotho, an essential coreceptor for FGF21, as a direct target gene of Rev-erbα in white adipose tissue but no  ...[more]

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