Sigma factor E of Mycobacterium tuberculosis controls the expression of bacterial components that modulate macrophages
Ontology highlight
ABSTRACT:
ORGANISM(S): Mycobacterium tuberculosis
SUBMITTER: MarÃa Alvarez
PROVIDER: E-GEOD-7962 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Mycobacterium tuberculosis sigma factor E regulon modulates the host inflammatory response.
Fontán Patricia A PA Aris Virginie V Alvarez María E ME Ghanny Saleena S Cheng Jeff J Soteropoulos Patricia P Trevani Analia A Pine Richard R Smith Issar I
The Journal of infectious diseases 20080901 6
Mycobacterium tuberculosis survives in macrophages and usually subverts the bactericidal mechanisms of these phagocytes. The understanding of this host-pathogen interaction is relevant for the development of new treatments for tuberculosis. The adaptation of M. tuberculosis to intracellular life depends on its ability to regulate the expression of its genes. Sigma factors are important bacterial transcription activators that bind to the RNA polymerase and give it promoter specificity. Sigma fact ...[more]
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