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Mycobacterium tuberculosis and macrophage response

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE6209: The global transcriptional profile of Mycobacterium tuberculosis during human macrophages infection GSE7962: Sigma factor E of Mycobacterium tuberculosis controls the expression of bacterial components that modulate macrophages Keywords: SuperSeries Refer to individual Series

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER: Virginie Aris

PROVIDER: E-GEOD-7963 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mycobacterium tuberculosis sigma factor E regulon modulates the host inflammatory response.

Fontán Patricia A PA Aris Virginie V Alvarez María E ME Ghanny Saleena S Cheng Jeff J Soteropoulos Patricia P Trevani Analia A Pine Richard R Smith Issar I

The Journal of infectious diseases 20080901 6

Mycobacterium tuberculosis survives in macrophages and usually subverts the bactericidal mechanisms of these phagocytes. The understanding of this host-pathogen interaction is relevant for the development of new treatments for tuberculosis. The adaptation of M. tuberculosis to intracellular life depends on its ability to regulate the expression of its genes. Sigma factors are important bacterial transcription activators that bind to the RNA polymerase and give it promoter specificity. Sigma fact ...[more]

PMID: 18657035

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Sigma factor E of Mycobacterium tuberculosis controls the expression of bacterial components that modulate macrophages

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