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Mapping interactions for the TNIP2 hub protein

ABSTRACT: This experiment analyzes the set of RNAs copurifying with the protein TNIP2 (amino acids 196-346) HEK293 cells were transfected with constructs expressing either Halo tag (controls) or Halo-TNIP2 196-346. Total RNA was purified from an aliquot of the whole cell extract (Input samples). Halo-tagged proteins were purified from the remainder of the whole cell extract, and RNA subsequently purified from the Halo purified samples (Pulldown samples).

ORGANISM(S): Homo sapiens

SUBMITTER: Gaye Hattem

PROVIDER: E-GEOD-79656 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

Banks Charles A S CA Boanca Gina G Lee Zachary T ZT Eubanks Cassandra G CG Hattem Gaye L GL Peak Allison A Weems Lauren E LE Conkright Juliana J JJ Florens Laurence L Washburn Michael P MP

Molecular & cellular proteomics : MCP 20160908 11

The NF-κB family of transcription factors is pivotal in controlling cellular responses to environmental stresses; abnormal nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling features in many autoimmune diseases and cancers. Several components of the NF-κB signaling pathway have been reported to interact with the protein TNIP2 (also known as ABIN2), and TNIP2 can both positively and negatively regulate NF-κB- dependent transcription of target genes. However, the func ...[more]

PMID: 27609421

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