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PI3K/AKT signaling regulates H3K4 methylation in breast cancer

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Koen Dreijerink

PROVIDER: E-GEOD-80594 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.

Spangle Jennifer M JM Dreijerink Koen M KM Groner Anna C AC Cheng Hailing H Ohlson Carolynn E CE Reyes Jaime J Lin Charles Y CY Bradner James J Zhao Jean J JJ Roberts Thomas M TM Brown Myles M

Cell reports 20160609 12

Post-translational histone H3 modifications regulate transcriptional competence. The mechanisms by which the epigenome is regulated in response to oncogenic signaling remain unclear. Here we show that H3K4me3 is increased in breast tumors driven by an activated PIK3CA allele and that inhibition of PI3K/AKT signaling reduces promoter-associated H3K4me3 in human breast cancer cells. We show that the H3K4 demethylase KDM5A is an AKT target and that phosphorylation of KDM5A regulates its nuclear loc ...[more]

PMID: 27292631

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