Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gene expression of extranodal NK/T cell lymphoma II

ABSTRACT: Gene expression profiling of extranodal nasal-type NK/T cell lymphoma and other EBV-associated lymphoid proliferation disease patients was analyzed to elucidate association between JAK-STAT pathway and canonical or non-canonical PRC2/EZH2 target pathways using Illumina HumanRef-8 v3 chips. In total, 47 samples were assayed in this data set. The non-normalized data were used for analysis. No normalization was performed.

ORGANISM(S): Homo sapiens

SUBMITTER: Siok-Bian Ng 

PROVIDER: E-GEOD-80631 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma.

Yan Junli J   Li Boheng B   Lin Baohong B   Lee Pei Tsung PT   Chung Tae-Hoon TH   Tan Joy J   Bi Chonglei C   Lee Xue Ting XT   Selvarajan Viknesvaran V   Ng Siok-Bian SB   Yang Henry H   Yu Qiang Q   Yu Qiang Q   Chng Wee-Joo WJ  

Blood 20160613 7

The best-understood mechanism by which EZH2 exerts its oncogenic function is through polycomb repressive complex 2 (PRC2)-mediated gene repression, which requires its histone methyltransferase activity. However, small-molecule inhibitors of EZH2 that selectively target its enzymatic activity turn out to be potent only for lymphoma cells with EZH2-activating mutation. Intriguingly, recent discoveries, including ours, have placed EZH2 into the category of transcriptional coactivators and thus rais  ...[more]

Similar Datasets

Transcriptomics Gene expression of extranodal NK/T cell lymphoma I
2016-07-26 | E-GEOD-80629 | biostudies-arrayexpress
Transcriptomics Gene expression of extranodal NK/T cell lymphoma
2016-07-26 | E-GEOD-80632 | biostudies-arrayexpress
Transcriptomics Gene expression of extranodal NK/T cell lymphoma II
2016-07-26 | GSE80631 | GEO
Transcriptomics Gene expression of extranodal NK/T cell lymphoma I
2016-07-26 | GSE80629 | GEO
Proteomics Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
2012-12-03 | E-GEOD-42673 | biostudies-arrayexpress
Genomics Molecular heterogeneity of NK/T-cell lymphoma [CNV]
2017-11-25 | GSE90777 | GEO
Transcriptomics Molecular heterogeneity of NK/T-cell lymphoma (expression)
2017-11-25 | GSE90597 | GEO
Genomics Gene expression of extranodal NK/T cell lymphoma
| PRJNA319539 | ENA
Genomics Molecular heterogeneity of NK/T-cell lymphoma [CNV supplementary]
2017-11-25 | GSE90783 | GEO
Genomics Molecular heterogeneity of NK/T-cell lymphoma (miRNA profiling)
2017-11-25 | GSE90774 | GEO