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Gene expression of extranodal NK/T cell lymphoma II

ABSTRACT: Gene expression profiling of extranodal nasal-type NK/T cell lymphoma and other EBV-associated lymphoid proliferation disease patients was analyzed to elucidate association between JAK-STAT pathway and canonical or non-canonical PRC2/EZH2 target pathways using Illumina HumanRef-8 v3 chips. In total, 47 samples were assayed in this data set. The non-normalized data were used for analysis. No normalization was performed.

ORGANISM(S): Homo sapiens

SUBMITTER: Siok-Bian Ng 

PROVIDER: E-GEOD-80631 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma.

Yan Junli J   Li Boheng B   Lin Baohong B   Lee Pei Tsung PT   Chung Tae-Hoon TH   Tan Joy J   Bi Chonglei C   Lee Xue Ting XT   Selvarajan Viknesvaran V   Ng Siok-Bian SB   Yang Henry H   Yu Qiang Q   Yu Qiang Q   Chng Wee-Joo WJ  

Blood 20160613 7

The best-understood mechanism by which EZH2 exerts its oncogenic function is through polycomb repressive complex 2 (PRC2)-mediated gene repression, which requires its histone methyltransferase activity. However, small-molecule inhibitors of EZH2 that selectively target its enzymatic activity turn out to be potent only for lymphoma cells with EZH2-activating mutation. Intriguingly, recent discoveries, including ours, have placed EZH2 into the category of transcriptional coactivators and thus rais  ...[more]

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