Project description:Gene expression profiling of extranodal nasal-type NK/T cell lymphoma and other EBV-associated lymphoid proliferation disease patients was analyzed to elucidate association between JAK-STAT pathway and canonical or non-canonical PRC2/EZH2 target pathways using Illumina HumanRef-8 v3 chips. In total, 47 samples were assayed in this data set. The non-normalized data were used for analysis. No normalization was performed.

2016-07-26 | E-GEOD-80631 | biostudies-arrayexpress

Gene expression of extranodal NK/T cell lymphoma I

Project description:Gene expression profiling of extranodal nasal-type NK/T cell lymphoma and other EBV-associated lymphoid proliferation disease patients was analyzed to elucidate association between JAK-STAT pathway and canonical or non-canonical PRC2/EZH2 target pathways using Illumina HumanRef-8 v3 chips. 6 samples in total in this data set. 3 from NKTL cell line, 3 from NKTL patient. The non-normalized data were used for analysis. No normalization was performed.

2016-07-26 | E-GEOD-80629 | biostudies-arrayexpress

Transcription profiling of natural-killer (NK) cell lymphoma to determine the disease molecular signature.

Project description:NK-cell lymphoma shares strikingly similar molecular features with a distinct subset of gamma-delta T-cell lymphoma. Gene expression profiling of NK-cell lymphoma patient samples was performed to investigate whether molecular signatures can be used to identify entities of peripheral T-cell lymphoma (PTCL) with NK-cell-like features. Gene expression profiling was performed on NK-cell maligancies to examine extranodal NK/T-cell lymphoma (ENKTL) and aggressive NK-cell leukemia (ANKL) and well-characterized cell lines of NK- and T-cell lineages to define molecular classifiers that can distinguish ENKTL from other lymphomas.

2010-03-18 | E-GEOD-19067 | biostudies-arrayexpress

Molecular heterogeneity of NK/T-cell lymphoma (expression)

Project description:To investigate if biologically distinct subsets exists in extranodal NK/T-cell lymphoma (NKTL), we performed unsupervised integrative analyses of gene expression profiling (GEP), miRNA profiling, and copy number aberration (CNA) on 66 cases of NKTL from diverse anatomical sites. This series is the GEP data.

2017-11-25 | GSE90597 | GEO

Whole-exome sequencing of extranodal NK/T cell lymphoma

Project description:Extranodal NK/T cell lymphoma (ENKTCL) is an aggressive Epstein-Barr virus-associated T/NK neoplasm that predominantly affects Asians. To explore the causative somatic events, we conducted a comprehensive genetic analysis of 19 ENKTCL patients including whole-exome sequencing (N = 16). Commonly deregulated gene pathways in ENKTCL included epigenetic modifiers followed by human leukocyte antigen (HLA) and related genes and JAK-STAT pathway.

| EGAS00001004357 | EGA

Molecular heterogeneity of NK/T-cell lymphoma [CNV]

2017-11-25 | GSE90777 | GEO

Molecular heterogeneity of NK/T-cell lymphoma [CNV supplementary]

2017-11-25 | GSE90783 | GEO

Molecular heterogeneity of NK/T-cell lymphoma (miRNA profiling)

2017-11-25 | GSE90774 | GEO