Gene expression signatures for primary tumor and tumor-derived exosomes
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Liu Yanfang
PROVIDER: E-GEOD-80678 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.
Liu Yanfang Y Gu Yan Y Han Yanmei Y Zhang Qian Q Jiang Zhengping Z Zhang Xiang X Huang Bo B Xu Xiaoqing X Zheng Jianming J Cao Xuetao X
Cancer cell 20160801 2
The pre-metastatic niche educated by primary tumor-derived elements contributes to cancer metastasis. However, the role of host stromal cells in metastatic niche formation and organ-specific metastatic tropism is not clearly defined. Here, we demonstrate that lung epithelial cells are critical for initiating neutrophil recruitment and lung metastatic niche formation by sensing tumor exosomal RNAs via Toll-like receptor 3 (TLR3). TLR3-deficient mice show reduced lung metastasis in the spontaneous ...[more]
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