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Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity

ABSTRACT: Genome wide DNA methylation profiling of human breast cancer cell lines, lowly invasive MCF10CA1h and highly invasive MCF10CA1a, treated with vehicle control (ethanol) and with RSV (resveratrol). The Illumina Infinium 450K Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 450,000 CpGs in human cell lines exposed to described treatments. Samples included biological triplicate of MCF10CA1h control (ethanol treated), biological triplicate of MCF10CA1h treated with RSV, biological triplicate of MCF10CA1a control (ethanol treated), biological triplicate of MCF10CA1a treated with RSV. Bisulphite converted DNA from the 12 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip v1.2

ORGANISM(S): Homo sapiens

SUBMITTER: Barbara Stefanska 

PROVIDER: E-GEOD-80794 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity.

Lubecka Katarzyna K   Kurzava Lucinda L   Flower Kirsty K   Buvala Hannah H   Zhang Hao H   Teegarden Dorothy D   Camarillo Ignacio I   Suderman Matthew M   Kuang Shihuan S   Andrisani Ourania O   Flanagan James M JM   Stefanska Barbara B  

Carcinogenesis 20160428 7

DNA hypomethylation was previously implicated in cancer progression and metastasis. The purpose of this study was to examine whether stilbenoids, resveratrol and pterostilbene thought to exert anticancer effects, target genes with oncogenic function for de novo methylation and silencing, leading to inactivation of related signaling pathways. Following Illumina 450K, genome-wide DNA methylation analysis reveals that stilbenoids alter DNA methylation patterns in breast cancer cells. On average, 75  ...[more]

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