Unknown,Transcriptomics,Genomics,Proteomics

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WT and irf3-/- macrophage response to WT L. monocytogenes

ABSTRACT: Transcriptional profiling of WT and irf3-/- macrophages infected with WT L. monocytogenes for 180 minutes Keywords: Cell type comparison. Experiment in different genetic backgrounds, with WT bacteria. Multiple biological replicates (see array names), with one replicate per array.

ORGANISM(S): Mus musculus

SUBMITTER: Jess Leber 

PROVIDER: E-GEOD-8101 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen.

Leber Jess H JH   Crimmins Gregory T GT   Raghavan Sridharan S   Meyer-Morse Nicole P NP   Cox Jeffery S JS   Portnoy Daniel A DA  

PLoS pathogens 20080101 1

How the innate immune system tailors specific responses to diverse microbial infections is not well understood. Cells use a limited number of host receptors and signaling pathways to both discriminate among extracellular and intracellular microbes, and also to generate responses commensurate to each threat. Here, we have addressed these questions by using DNA microarrays to monitor the macrophage transcriptional response to the intracellular bacterial pathogen Listeria monocytogenes. By utilizin  ...[more]

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