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WT macrophage response to transfected bacterial ligands

ABSTRACT: Transcriptional profiling of WT macrophages transfected with L. monocytogenes genomic DNA, synthetic MDP, or both Keywords: Ligand comparison. Experiment in WT background, with different combinations of bacterial ligands. Multiple biological replicates (see array names), with one replicate per array.

ORGANISM(S): Mus musculus

SUBMITTER: Jess Leber

PROVIDER: E-GEOD-8103 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen.

Leber Jess H JH Crimmins Gregory T GT Raghavan Sridharan S Meyer-Morse Nicole P NP Cox Jeffery S JS Portnoy Daniel A DA

PLoS pathogens 20080101 1

How the innate immune system tailors specific responses to diverse microbial infections is not well understood. Cells use a limited number of host receptors and signaling pathways to both discriminate among extracellular and intracellular microbes, and also to generate responses commensurate to each threat. Here, we have addressed these questions by using DNA microarrays to monitor the macrophage transcriptional response to the intracellular bacterial pathogen Listeria monocytogenes. By utilizin ...[more]

PMID: 18193943

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WT macrophage response to transfected bacterial ligands

Project description:Transcriptional profiling of WT macrophages transfected with L. monocytogenes genomic DNA, synthetic MDP, or both Keywords: Ligand comparison.

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Intracellular transcription by multiple Listeria monocytogenes strains

Project description:These studies were designed to examine the transcription of Listeria monocytogenes strains 10403S and LO28 during intracellular replication in mammalian macrophages. Duplicate WT Listeria monocytogenes (strains 10403S and LO28) were used to infect mouse bone marrow-derived macrophages (BMMs). Bacterial RNA was harvested at 4 hours post-infection.

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Project description:We infected the bone marrow-derived macrophages (BMDM) isolated from WT, Stat1Y701F or Stat1-/- mice were infected with Listeria monocytogenes for 6, 12 or 24h, or left untreated in order to find out how the transcriptome of these genotypes differs during infection.

2016-01-26 | E-MTAB-3598 | biostudies-arrayexpress

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Transcriptomic profile of porcine corpus luteum after PPAR gamma ligands treatment

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