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Transcription profiling of mouse heart after dietary supplementation of vitamin E in the mouse heart to investigate age-related transcriptional changes

ABSTRACT: To investigate the global effects of vitamin E supplementation on heart aging, we used high-density oligonucleotide arrays to measure transcriptional alterations in 30-month-old B6C3F1 mice supplemented with Î±- and Î³-tocopherol since middle age (15 months). Experiment Overall Design: Gene expression profiles were obtained from 5-month-old controls, 30-month-old controls and 30-month-old mice supplemented with Î±-tocopherol (1g/kg), or a mixture of Î±- and Î³-tocopherol (500mg/kg of each tocopherol).

ORGANISM(S): Mus musculus

SUBMITTER: Sang-Kyu Park

PROVIDER: E-GEOD-8146 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcription profiling of mouse heart and brain to investigate age-related transcriptional changes and the effect of dietary supplementation of vitamin E

Project description:This SuperSeries is composed of the following subset Series:; GSE8146: Age-related transcriptional changes and the effect of dietary supplementation of vitamin E in the mouse heart; GSE8150: Age-related transcriptional changes and the effect of dietary supplementation of vitamin E in the mouse brain Experiment Overall Design: Refer to individual Series

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Transcription profiling of chicken liver after alpha- and gamma-tocopherol supplementation in case of increased oxidative stress susceptibility

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Enhanced Phospholipase A2 group 3 expression by oxidative stress decreases the insulin-degrading enzyme

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