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Hippocampal gene expression signature in autistic BTBR mice

ABSTRACT: Autism spectrum disorders (ASD) are characterized by a high degree of genetic heterogeneity. Genomic studies identified common pathological processes underlying the heterogeneous clinical manifestations of ASD, and transcriptome analyses revealed that gene networks involved in synapse development, neuronal activity and immune function are deregulated in ASD. Mouse models provide unique tools to investigate the neurobiological basis of ASD. Here we used the BTBR (BTBR T+ Itpr3tf/J) ASD mouse model to identify conserved ASD-related molecular signatures. Gene expression in the BTBR mouse hippocampus was measured by microarrays and compared to the gene expression profile of C57Bl6/J controls (5 months old, n= 4 mice per group).

ORGANISM(S): Mus musculus

SUBMITTER: Yuri Bozzi

PROVIDER: E-GEOD-81501 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Prefrontal cortex gene expression signature in autistic BTBR mice

Project description:Autism spectrum disorders (ASD) are characterized by a high degree of genetic heterogeneity. Genomic studies identified common pathological processes underlying the heterogeneous clinical manifestations of ASD, and transcriptome analyses revealed that gene networks involved in synapse development, neuronal activity and immune function are deregulated in ASD. Mouse models provide unique tools to investigate the neurobiological basis of ASD. Here we used the BTBR (BTBR T+ Itpr3tf/J) ASD mouse model to identify conserved ASD-related molecular signatures. Gene expression in the BTBR mouse prefrontal cortex was measured by microarrays and compared to the gene expression profile of C57Bl6/J controls (5 months old, n= 3 mice per group).

2016-05-18 | E-GEOD-81502 | biostudies-arrayexpress

Hippocampal gene expression signature in autistic BTBR mice

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Prefrontal cortex gene expression signature in autistic BTBR mice

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Comprehensive profiling of gene expression in the cerebral cortex and striatum of BTBRTF/ArtRbrc mice compared to C57BL/6J mice

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Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors

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Increased expression of SLC25A1/CIC in the mouse results in an autistic-like phenotype with altered white matter microstructure and neuron morphology

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RNA-seq of autistic and control cortex

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2014-12-09 | E-GEOD-64018 | biostudies-arrayexpress

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Cytogenetics 2.7M and Cytoscan HD 2.8M Microarrays in autistic families in the Lebanese population

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