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Antifungal effect of Sesamol (Ses) on C. albicans SC5314

ABSTRACT: Transcriptional profiling of Candida cells comparing the control vs Ses treated cells Organism : Candida albicans, Agilent custom C.albicans Gene Expression 8x15k Array (AMADID: 026377) designed by Genotypic Technology Private Limited

ORGANISM(S): Candida albicans

SUBMITTER: Saif Hameed

PROVIDER: E-GEOD-83080 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mechanistic insights into the mode of action of anticandidal sesamol.

Ansari Moiz A MA Fatima Zeeshan Z Hameed Saif S

Microbial pathogenesis 20160705

Previously we have deciphered the antifungal effect of sesamol (Ses), a phenolic compound obtained from sesame oil, against human fungal pathogen Candida albicans. To gain deeper insights into the possible mechanisms involved, transcription profiling was done in presence of Ses which revealed various targets through which Ses was barricading the growth of C. albicans. We observed that Ses perturbs membrane integrity confirming our previous observations and displayed disrupted plasma membrane ATP ...[more]

PMID: 27392701

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