Genotyping of human neuroblastoma tumors
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Rani George
PROVIDER: E-GEOD-8333 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays.
George Rani E RE Attiyeh Edward F EF Li Shuli S Moreau Lisa A LA Neuberg Donna D Li Cheng C Fox Edward A EA Meyerson Matthew M Diller Lisa L Fortina Paolo P Look A Thomas AT Maris John M JM
PloS one 20070228 2
<h4>Background</h4>Neuroblastomas are characterized by chromosomal alterations with biological and clinical significance. We analyzed paired blood and primary tumor samples from 22 children with high-risk neuroblastoma for loss of heterozygosity (LOH) and DNA copy number change using the Affymetrix 10K single nucleotide polymorphism (SNP) array.<h4>Findings</h4>Multiple areas of LOH and copy number gain were seen. The most commonly observed area of LOH was on chromosome arm 11q (15/22 samples; 6 ...[more]
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