Genomics

Dataset Information

0

A compendium of myeloma associated chromosomal copy number abnormalities and their prognostic value


ABSTRACT: To obtain a comprehensive genomic profile of presenting multiple myeloma cases we performed high resolution single nucleotide polymorphism (SNP) mapping array analysis in 114 samples alongside 258 samples analysed by U133 Plus 2.0 expression array (Affymetrix). We examined DNA copy number alterations and loss of heterozygosity (LOH) in order to define the spectrum of minimally deleted regions in which relevant genes of interest can be found. The most frequent deletions are located at 1p (30%), 6q (33%), 8q (25%), 12 (22%), 13q (59%), 14q (39%), 16q (35%), 17p (7%), 20 (12%) and 22 (18%). In addition, copy number-neutral LOH, or uniparental disomy, was also prevalent on 1q (8%), 16q (9%), and X (20%), and was associated with regions of gain and loss. Based on fluorescent in situ hybridisation (FISH) and expression quartile analysis, genes of prognostic importance were found to be located at 1p (FAF1, CDKN2C), 1q (ANP32E), and 17p (TP53). In addition, we identified common homozygously deleted genes which have functions relevant to myeloma biology. Taken together, the dysregulated genes from the myeloma genome indicate that the crucial pathways in myeloma pathogenesis include the NF-?B pathway, apoptosis, cell-cycle regulation and Wnt signalling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE21349 | GEO | 2010/10/18

SECONDARY ACCESSION(S): PRJNA126129

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2010-11-02 | E-GEOD-21349 | biostudies-arrayexpress
2016-02-18 | GSE77975 | GEO
2008-06-16 | E-GEOD-8333 | biostudies-arrayexpress
2012-10-12 | GSE39381 | GEO
2012-10-12 | GSE39380 | GEO
2007-06-30 | GSE8333 | GEO
2012-10-12 | E-GEOD-39380 | biostudies-arrayexpress
2008-06-16 | E-GEOD-8123 | biostudies-arrayexpress
2008-06-14 | E-GEOD-6205 | biostudies-arrayexpress
2007-10-22 | GSE7130 | GEO