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Transcription profiling of inner ears from Errb mutant mice and wild type littermate controls

ABSTRACT: Transcriptional profiles were compared in microdissected lateral walls of the inner ears from Errb mutant mice and wild type littermate controls. The goal is to identify transcriptional targets of Errb and candidate genes for inner ear diseases. Experiment Overall Design: Errb mutant mice were generated by conditional knock-out strategy. Inner ears from 10 mice were pooled for each sample and 3 replicates of wild type and mutant samples were analyzed.

ORGANISM(S): Mus musculus

SUBMITTER: Jichao Chen

PROVIDER: E-GEOD-8434 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis.

Chen Jichao J Nathans Jeremy J

Developmental cell 20070901 3

In the mammalian inner ear, endolymph is produced and resorbed by a complex series of epithelia. We show here that estrogen-related receptor beta (ERR-beta; NR3B2), an orphan nuclear receptor, is specifically expressed in and controls the development of the endolymph-producing cells of the inner ear: the strial marginal cells in the cochlea and the vestibular dark cells in the ampulla and utricle. Nr3b2(-/-) strial marginal cells fail to express multiple ion channel and transporter genes, and th ...[more]

PMID: 17765677

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