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GE expression profile of PBMCs in healthy subjects and MS patients after extra virgin olive oil (EVOO) intake - PART 3 - MS Patients

ABSTRACT: Gene expression profiles of PBMCs in patients with MS following extra virgin olive oil intake. The aim of the present study was to investigate the whole-genome gene and miRNA profiles of after EVOO intake. Results provide the information of changes in PBMCs transcriptome following EVOO intake. RNA obtained from PBMCs of the same patients before and after extra virgin olive oil intake (paired samples). Comparisons: T0 vs. T1 (paired samples)

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Moschetta

PROVIDER: E-GEOD-84591 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil.

D'Amore Simona S Vacca Michele M Cariello Marica M Graziano Giusi G D'Orazio Andria A Salvia Roberto R Sasso Rosa Cinzia RC Sabbà Carlo C Palasciano Giuseppe G Moschetta Antonio A

Biochimica et biophysica acta 20160712 11

Extra virgin olive oil (EVOO) consumption has been associated with reduced cardiovascular risk but molecular mechanisms underlying its beneficial effects are not fully understood. Here we aimed to identify genes and miRNAs expression changes mediated by acute high- and low-polyphenols EVOO intake. Pre- and post-challenge gene and miRNAs expression analysis was performed on the peripheral blood mononuclear cells (PBMCs) of 12 healthy subjects and 12 patients with metabolic syndrome (MS) by using ...[more]

PMID: 27422371

Similar Datasets

Gene expression profile of PBMCs in healthy subjects and MS Patients after extra virgin olive oil (EVOO) intake - Part 1 (Controls)

Project description:Gene expression profiles of PBMCs in healthy subjects following extra virgin olive oil intake. The aim of the present study was to investigate the whole-genome gene and miRNA profiles of after EVOO intake. Results provide the information of changes in PBMPs transcriptome following EVOO intake. RNA obtained from PBMCs of the same subjects before and after extra virgin olive oil intake (paired samples). Comparisons: T0 vs. T1 (paired samples) - Controls

2016-07-19 | E-GEOD-75025 | biostudies-arrayexpress

miRNA expression profile of PBMCs in healthy subjects after extra virgin olive oil (EVOO) intake - Part 2 (Controls)

Project description:miRNA expression profiles of PBMCs in healthy subjects following extra virgin olive oil intake. The aim of the present study was to investigate the whole-genome gene and miRNA profiles of PBMCs after EVOO intake. Results provide the information of changes in PBMPs transcriptome following EVOO intake. RNA obtained from PBMCs of the same patients before and after extra virgin olive oil intake (paired samples). Comparisons: T0 vs. T1 (paired samples) - Controls

2016-07-19 | E-GEOD-75026 | biostudies-arrayexpress

GE expression profile of PBMCs in healthy subjects and MS patients after extra virgin olive oil (EVOO) intake - PART 3 - MS Patients

Project description:Gene expression profiles of PBMCs in patients with MS following extra virgin olive oil intake. The aim of the present study was to investigate the whole-genome gene and miRNA profiles of after EVOO intake. Results provide the information of changes in PBMCs transcriptome following EVOO intake.

2016-07-19 | GSE84591 | GEO

Gene expression profile of PBMCs in healthy subjects and MS Patients after extra virgin olive oil (EVOO) intake - Part 1 (Controls)

2016-07-19 | GSE75025 | GEO

miRNA expression profile of PBMCs in healthy subjects after extra virgin olive oil (EVOO) intake - Part 2 (Controls)

2016-07-19 | GSE75026 | GEO

Detection of plant microRNAs in EVOO and plasma samples of healthy volunteers 2 hours postingestion of 40 mL of EVOO.

Project description:NGS has been applied to microRNA-enriched RNA obtained from Extra Virgin Olive Oil (EVOO), beer and plasma samples of healthy volunteers that usually consume EVOO hours after the ingestion of 40 mL of EVOO. Results: We did not detect significant amount of microRNA in the EVOO samples. Plasma samples did not contain EVOO microRNAs nor other microRNAs from plant origin.

2016-06-30 | GSE76735 | GEO

Detection of plant microRNAs in EVOO and plasma samples of healthy volunteers 2 hours postingestion of 40 mL of EVOO.

2016-06-30 | E-GEOD-76735 | biostudies-arrayexpress

Transcription profiling of colon mucosa from HLAB27 transgenic rats fed extra-virgin olive oil rich in polyphenols

Project description:HLA-B27 transgenic rats, experimental model of chronic colitis, fed with a diet in which the lipid component was provided by corn oil (CO group), extra-virgin olive oil rich in phenols, 718.8 mg of total phenols/kg of olive oil (EVOO group) or the same extra-virgin olive oil, deprived of phenolic compounds but retaining other minor components such as a-tocopherol (ROO group).

2018-11-26 | E-MTAB-6218 | biostudies-arrayexpress

GE/miRNA expression profile of PBMCs in healthy subjects and MS patients after extra virgin olive oil (EVOO) intake

Project description:GE/miRNA expression profile of PBMCs in healthy subjects and MS patients after extra virgin olive oil (EVOO) intake

| PRJNA302256 | ENA

Olive oil phenols and GE in the aging mouse brain

Project description:The aim of this study was to evaluate whether the dietary treatment with olive oil phenols modifies the profile of microRNA and gene expression in different areas of the aging mouse brain and to correlate these changes with the cognitive and motor changes observed in the same aging animals. C57Bl/6J mice were fed from middle age to senescence with extra-virgin olive oil (10% wt/wt dry diet) rich in polyphenols (H-EVOO group, total polyphenol dose/day, 6mg/kg) or with the same extra-virgin olive oil deprived of phenolic compounds (L-EVOO group). By whole gene expression analysis we identified 53 genes differentially expressed in the cortex of H-EVOO mice compared to L-EVOO mice and no genes differentially expressed in the cerebellum. Gene Set Expression analysis (GSEA) found 6 gene sets significantly modulated by the dietary treatments in cortex, like the agrin-related postsynaptic differentiation gene set, involved in cholinergic synaptic differentiation and maintenance, exerting effects on axonal and dendritic growth. miRNA profiling found only 6 miRNA differentially modulated after 12 months of feeding and 63 after six months. Among them we noted miRNAs previously associated to neurodegenerative disorders such as mir101, 8.5 time more expressed in the cortex of L-EVOO fed mice compared to the H-EVOO group and no expressed in young mice. We extended our analysis on cortex harvested from transgenic TgCRND8 mice, a model of Alzheimer's disease, observing an overall down-regulation of miRNAs compared to mice of the same age. On the contrary, the H-EVOO fed mice cortex showed expression profiles similar to those of young mice, results supporting our previous data demonstrating that extra virgin olive oil rich in polyphenols may improve some age-related dysfunctions.

2013-09-10 | E-MTAB-1530 | biostudies-arrayexpress

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