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Effect of from Human Umbilical Vein Endothelial Cells

ABSTRACT: We profiled global gene expression in primary human umbilical vein endothelial cells to determine the gene expression changes associated with knocking down PKM2 and p53. We identified a p53 dependent transcriptional response that remodels metabolism in cells lacking p53, thus limiting cell growth. Human Umbilical Vein Endothelial Cells were transfected with siRNA duplexes targeting PKM2 and / or p53, RNA was extracted and subjected to RNA sequencing

ORGANISM(S): Homo sapiens

SUBMITTER: Carsten Kuenne

PROVIDER: E-GEOD-84877 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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