Analysis of effect of sirt1 deficiency on global gene expression in testis
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: rich allsopp
PROVIDER: E-GEOD-8492 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Sirt1 deficiency attenuates spermatogenesis and germ cell function.
Coussens Matthew M Maresh John G JG Yanagimachi Ryuzo R Maeda Gregg G Allsopp Richard R
PloS one 20080213 2
In mammals, Sirt1, a member of the sirtuin family of proteins, functions as a nicotinamide adenine dinucleotide-dependent protein deactylase, and has important physiological roles, including the regulation of glucose metabolism, cell survival, and mitochondrial respiration. The initial investigations of Sirt1 deficient mice have revealed a phenotype that includes a reduced lifespan, small size, and an increased frequency of abnormal sperm. We have now performed a detailed analysis of the molecul ...[more]
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