Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of adipocytes and stromo-vascular fraction from subcutaneous and intraabdominal mouse adipose tissue

ABSTRACT: Obesity is an epidemic health problem worldwide that impacts the risk and prognosis of many diseases. However, not all obese patients have the same risk of developing these disorders. Individuals with peripheral obesity, i.e., fat distributed subcutaneously, are at little or no risk of the common medical complications of obesity, whereas individuals with central obesity, i.e., fat accumulated in visceral depots, are prone to these complications. In the present study, using microaarays gene expression, we have explored the hypothesis that patterns of fat distribution and, perhaps, to some degree, obesity itself may have a developmental genetic origin. Experiment Overall Design: Isolated adipocytes and stromo-vascular fraction (SVF) of subcutaneous and intraabdominal adipose tissue of mice were used for RNA extraction and hybridization on Affymetrix microarrays. Three samples from each categories were used for the analyse.

ORGANISM(S): Mus musculus

SUBMITTER: Stephane Gesta

PROVIDER: E-GEOD-8505 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Evidence for a role of developmental genes in the origin of obesity and body fat distribution.

Gesta Stephane S Blüher Matthias M Yamamoto Yuji Y Norris Andrew W AW Berndt Janin J Kralisch Susan S Boucher Jeremie J Lewis Choy C Kahn C Ronald CR

Proceedings of the National Academy of Sciences of the United States of America 20060414 17

Obesity, especially central obesity, is a hereditable trait associated with a high risk for development of diabetes and metabolic disorders. Combined gene expression analysis of adipocyte- and preadipocyte-containing fractions from intraabdominal and subcutaneous adipose tissue of mice revealed coordinated depot-specific differences in expression of multiple genes involved in embryonic development and pattern specification. These differences were intrinsic and persisted during in vitro culture a ...[more]

PMID: 16617105

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Dataset Information

Transcription profiling of adipocytes and stromo-vascular fraction from subcutaneous and intraabdominal mouse adipose tissue

Publications

Evidence for a role of developmental genes in the origin of obesity and body fat distribution.

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