Transcription profiling of human monocyte derived macrophages response to IL-1 and IL-6
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ABSTRACT: Using whole-genome Affymetrix microarrays (HG-U133A), we characterized the transcriptome profile of cultured human macrophages stimulated for 4 h with interleukin 1 (IL-1) or interleukin 6 (IL-6). We found that, in distinction to liver cells, IL-1 is much more potent than IL-6 in modifying macrophage gene expression, although considerable heterogeneity in response of macrophages deriving from individual blood donors was observed. The obtained results permitted to identify a large number of cytokine-responsive genes. coding for proteins of unknown function that are now being studied in our laboratory. They may represent novel targets in the anti-inflammatory therapy. Experiment Overall Design: Analysis of the transcriptome of human monocyte-derived macrophages stimulated in vitro by low doses of IL-1 or IL-6.
ORGANISM(S): Homo sapiens
SUBMITTER: Marcin Piechota
PROVIDER: E-GEOD-8515 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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