Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human measles virus-infected dendritic cells


ABSTRACT: Human CD14+ monocytes were isolated and grown in GM-CSF and IL-4 for six days. The cells were then infected with measles virus, Chicago-1 strain, and RNA was isolated at 3, 6, 12, and 24 hours post-infection.

ORGANISM(S): Homo sapiens

DISEASE(S): measles virus infected

SUBMITTER: Michael Zilliox 

PROVIDER: E-GEOD-980 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression patterns in dendritic cells infected with measles virus compared with other pathogens.

Zilliox Michael J MJ   Parmigiani Giovanni G   Griffin Diane E DE  

Proceedings of the National Academy of Sciences of the United States of America 20060221 9


Gene expression patterns supply insight into complex biological networks that provide the organization in which viruses and host cells interact. Measles virus (MV) is an important human pathogen that induces transient immunosuppression followed by life-long immunity in infected individuals. Dendritic cells (DCs) are potent antigen-presenting cells that initiate the immune response to pathogens and are postulated to play a role in MV-induced immunosuppression. To better understand the interaction  ...[more]

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