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Salmonella Typhimurium transcription profiles in space flight

ABSTRACT: Salmonella transcription profiles were obtained from samples flown on space shuttle mission STS-115, and compared to profiles from Salmonella grown under identical conditions on the ground. Keywords: stress response, transcriptional profile Triplicate experimental samples were hybridized to slides that contain three identical Salmonella ORF arrays. Each hybridization was performed with Cy3 labeled total RNA and Cy5 labeled gDNA as control.

ORGANISM(S): Salmonella enterica

SUBMITTER: Michael McClelland 

PROVIDER: E-GEOD-8573 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq.

Wilson J W JW   Ott C M CM   Höner zu Bentrup K K   Ramamurthy R R   Quick L L   Porwollik S S   Cheng P P   McClelland M M   Tsaprailis G G   Radabaugh T T   Hunt A A   Fernandez D D   Richter E E   Shah M M   Kilcoyne M M   Joshi L L   Nelman-Gonzalez M M   Hing S S   Parra M M   Dumars P P   Norwood K K   Bober R R   Devich J J   Ruggles A A   Goulart C C   Rupert M M   Stodieck L L   Stafford P P   Catella L L   Schurr M J MJ   Buchanan K K   Morici L L   McCracken J J   Allen P P   Baker-Coleman C C   Hammond T T   Vogel J J   Nelson R R   Pierson D L DL   Stefanyshyn-Piper H M HM   Nickerson C A CA  

Proceedings of the National Academy of Sciences of the United States of America 20070927 41

A comprehensive analysis of both the molecular genetic and phenotypic responses of any organism to the space flight environment has never been accomplished because of significant technological and logistical hurdles. Moreover, the effects of space flight on microbial pathogenicity and associated infectious disease risks have not been studied. The bacterial pathogen Salmonella typhimurium was grown aboard Space Shuttle mission STS-115 and compared with identical ground control cultures. Global mi  ...[more]

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