IPSC-Derived Cholangiocytes

ABSTRACT: Human iPS cells were differentiated to cholangiocyte-like cells thorugh five phases of endodermal differentiation. Human iPSC were generated by forced expression of the Yamanaka pluripotency factors. We then pursued a stepwise differentiation strategy toward iDCs, using precise temporal exposure to key biliary morphogens, and we characterized the cells, using a variety of morphologic, molecular, cell biologic, functional, and in vivo approaches.

ORGANISM(S): Homo sapiens

SUBMITTER: Asha Nair 

PROVIDER: E-GEOD-86007 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress