Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of mouse liver from animals that vary in adiposity and insulin sensitivity


ABSTRACT: Adipose tissue gene expression was profiled from perigonadal adipose tissue of mice whose body mass and insulin sensitivity varied as a function of diet, gender, monogenic mutations and insulin sensitizing therapies. Mice were 22-24 weeks of age and sacrificed between 2-3 hours into the light portion of a 12/12 dark-light cycle. The goal was to identify transcripts whose adipose tissue expression is correlated with adiposity, insulin sensitivity and other measures of metabolic function. Experiment Overall Design: Mice on the C57BL/6J strain were housed in groups of 3-5 and fed ad libitum. 2-4 days prior to collection of adipose tissue fasting blood glucose and serum insulin concentrations were measured. Mice were sacrificed 2-3 hours into the light cycle. RNA was extracted from perigonadal adipose tissue and used to generate labed cRNA for hybridization to Affymetrix Mu74Av2 microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Anthony Ferrante 

PROVIDER: E-GEOD-8831 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2008-11-01 | GSE8831 | GEO
2019-02-26 | GSE113407 | GEO
2019-02-26 | GSE113406 | GEO
2016-06-30 | E-GEOD-70123 | biostudies-arrayexpress
2016-06-30 | GSE70123 | GEO
2010-05-28 | E-GEOD-21754 | biostudies-arrayexpress
2019-05-09 | GSE129518 | GEO
2016-07-01 | E-GEOD-63510 | biostudies-arrayexpress
2020-07-22 | GSE154832 | GEO
2023-11-06 | PXD045836 | Pride