Ontology highlight
ABSTRACT:
ORGANISM(S): Mycobacterium tuberculosis
SUBMITTER: SMD Staff
PROVIDER: E-GEOD-8839 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Voskuil Martin I MI Schnappinger Dirk D Visconti Kevin C KC Harrell Maria I MI Dolganov Gregory M GM Sherman David R DR Schoolnik Gary K GK
The Journal of experimental medicine 20030901 5
An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the mechanisms by which M. tuberculosis survives within latent lesions are compelling but unanswered questions. One such host factor may be nitric oxide (NO), a product of activated macrophages that exhibits antimycobacterial properties. Evidence for the possible significance of NO comes from murine models of tuberculosis showing progressive in ...[more]