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Mouse colon expression in wild type and STAT5b deficient mice

ABSTRACT: Regulation of epithelial barrier function is dependent upon precise control of cell survival and activation of inflammatory pathways in response to the enteric flora. These experiments tested differential colon gene expression relative to these pathways in wild type and STAT5b deficient mice. Keywords: Single time point in wild type and STAT5b deficient mice. Colon RNA was isolated from adult wild type and STAT5b deficient mice.

ORGANISM(S): Mus musculus

SUBMITTER: Xiaonan Han

PROVIDER: E-GEOD-8942 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Regulation of intestinal barrier function by signal transducer and activator of transcription 5b.

Han X X Ren X X Jurickova I I Groschwitz K K Pasternak B A BA Xu H H Wilson T A TA Hogan S P SP Denson L A LA

Gut 20080807 1

<h4>Background</h4>Colon epithelial cell (CEC) apoptosis and nuclear factor-kappaB (NF-kappaB) activation may compromise barrier function, and it has been reported that signal transducer and activator of transcription 5b (STAT5b)-deficient mice exhibit increased susceptibility to colitis. It is hypothesised that the growth hormone (GH) target STAT5b maintains mucosal barrier integrity by promoting CEC survival and inhibiting NF-kappaB activation.<h4>Methods</h4>The GH effect upon mucosal injury ...[more]

PMID: 18687707

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