Extended Primate aCGH
Ontology highlight
ABSTRACT:
ORGANISM(S): Callithrix sp.
SUBMITTER: Young Kim
PROVIDER: E-GEOD-9028 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene copy number variation spanning 60 million years of human and primate evolution.
Dumas Laura L Kim Young H YH Karimpour-Fard Anis A Cox Michael M Hopkins Janet J Pollack Jonathan R JR Sikela James M JM
Genome research 20070731 9
Given the evolutionary importance of gene duplication to the emergence of species-specific traits, we have extended the application of cDNA array-based comparative genomic hybridization (aCGH) to survey gene duplications and losses genome-wide across 10 primate species, including human. Using human cDNA arrays that contained 41,126 cDNAs, corresponding to 24,473 unique human genes, we identified 4159 genes that likely represent most of the major lineage-specific gene copy number gains and losses ...[more]
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