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Oral dysplasias and oral squamous cell carcinoma

ABSTRACT: Analysis of DNA from 94 oral lesions by whole genome tiling-path array comparative genomic hybridization. Keywords: array comparative genomic hybridization Whole genome tiling-path array CGH profiles of 94 formalin-fixed paraffin-embedded oral specimens.

ORGANISM(S): Homo sapiens

SUBMITTER: Miriam Rosin

PROVIDER: E-GEOD-9193 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Multiple aberrations of chromosome 3p detected in oral premalignant lesions.

Tsui Ivy F L IF Rosin Miriam P MP Zhang Lewei L Ng Raymond T RT Lam Wan L WL

Cancer prevention research (Philadelphia, Pa.) 20081101 6

The study of oral premalignant lesions (OPL) is crucial to the identification of initiating genetic events in oral cancer. However, these lesions are minute in size, making it a challenge to recover sufficient DNA from microdissected cells for comprehensive genomic analysis. As a step toward identifying genetic aberrations associated with oral cancer progression, we used tiling-path array comparative genomic hybridization to compare alterations on chromosome 3p for 71 OPLs against 23 oral squamo ...[more]

PMID: 19138989

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