Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

54 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Oral dysplasias and oral squamous cell carcinoma

ABSTRACT: Analysis of DNA from 94 oral lesions by whole genome tiling-path array comparative genomic hybridization. Keywords: array comparative genomic hybridization Whole genome tiling-path array CGH profiles of 94 formalin-fixed paraffin-embedded oral specimens.

ORGANISM(S): Homo sapiens

SUBMITTER: Miriam Rosin

PROVIDER: E-GEOD-9193 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Multiple aberrations of chromosome 3p detected in oral premalignant lesions.

Tsui Ivy F L IF Rosin Miriam P MP Zhang Lewei L Ng Raymond T RT Lam Wan L WL

Cancer prevention research (Philadelphia, Pa.) 20081101 6

The study of oral premalignant lesions (OPL) is crucial to the identification of initiating genetic events in oral cancer. However, these lesions are minute in size, making it a challenge to recover sufficient DNA from microdissected cells for comprehensive genomic analysis. As a step toward identifying genetic aberrations associated with oral cancer progression, we used tiling-path array comparative genomic hybridization to compare alterations on chromosome 3p for 71 OPLs against 23 oral squamo ...[more]

PMID: 19138989

Similar Datasets

Tiling-set aCGH data for oral dysplasias and oral squamous cell carcinomas

Project description:Analysis of DNA from 89 oral lesions by whole genome tiling-path array comparative genomic hybridization. Keywords: array comparative genomic hybridization Genomic DNA isolated from 89 formalin-fixed paraffin-embedded oral dysplasias and tumors, then profiled by whole genome tiling-path array CGH to identify DNA copy alterations for each case.

2009-07-01 | E-GEOD-11275 | biostudies-arrayexpress

Oral dysplasias and oral squamous cell carcinoma

Project description:Analysis of DNA from 94 oral lesions by whole genome tiling-path array comparative genomic hybridization. Keywords: array comparative genomic hybridization

2008-12-31 | GSE9193 | GEO

Tiling-set aCGH data for oral dysplasias and oral squamous cell carcinomas

Project description:Analysis of DNA from 89 oral lesions by whole genome tiling-path array comparative genomic hybridization. Keywords: array comparative genomic hybridization

2009-07-01 | GSE11275 | GEO

Array-CGH of malignant peripheral nerve sheath tumors (MPNST)

Project description:Comparison of copy number changes in MPNST samples against benign neurofibromas in NF1 patients 24 MPNSTs and 3 NF samples were hybridised to the human 32K BAC tiling path array

2010-05-18 | E-GEOD-16041 | biostudies-arrayexpress

Transcription profiling of mouse IL-9tg mutants in a balb/c background reveals mIL-9/mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity

Project description:Small intestine of a pool of three Wt mice and a pool of 3 IL-9tg mice in a balb/c backround. We demonstrated that intestinal IL-9 over expression predispose to oral antigen sensitization Experiment Overall Design: In the study, we hybridized RNA from 6-8 week old small intestine of wild type (WT) control and Interleukin 9 (IL-9Tg) to Affymetrix MOE430 2 GeneChipÂ® arrays. Each sample is a pool of three mice.

2008-04-06 | E-GEOD-10658 | biostudies-arrayexpress

Gene expression profiling in Daphnia magna, Part III: Uncovering Biomarkers for Metal and ORC exposures

Project description:To determine toxicant specific effects of Ordnance Related Compound (ORC) exposure we performed microarray hybridizations with RNA isolated from Daphnia magna following different ORC exposures at the 1/10 LC50. The gene expression profiles revealed toxicant specific gene expression profiles allowed for the identification of specific biomarkers of exposure. Keywords: ecotoxicogenomic exposure study We exposed Daphnia magna the 1/10 LC50 of different Ordnance Related Compounds (Cu, Zn, Pb, WO4, RDX, TNT, 2-ADNT, 2-ADNT, TNB, DNB, 2,4-DNT, and 2,6-DNT) for 24 hours. For each exposure condition, we performed 3 exposures and 2 technical replicates (as dye swap) for each exposure (6 microarrays total, except TNT and Cu). All exposures were compared to a unexposed laboratory control (MHRW media).

2010-05-18 | E-GEOD-13169 | biostudies-arrayexpress

RNAseq analysis of samples from oral cancer and oral leukoplakias patients

Project description:RNAseq analysis of oral cancer and oral leukoplakia patients. Oral biopsies from 37 patients were obtained for sequencing using RNAseq including control, oral leukoplakia patients and oral cancer patients.

2022-10-08 | E-MTAB-12205 | biostudies-arrayexpress

Expression data from fibroblasts derived from human normal oral mucosa, oral dysplasia and oral squamous cell carcinoma

Project description:Identification of genes that are differentially regulated in fibroblasts derived from dysplastic oral mucosa and oral squamous cell carcinoma compared to fibroblasts derived from normal oral mucosa. Affymetrix microarrays were used to define differential gene expression. Populations of fibroblasts were isolated from human normal oral mucosa, oral dysplasia and oral squamous cell carcinoma, maintained in 3D collagen I biomatrices, RNA extracted and processed for Affymetrix arrays. Fibroblasts maintained as monolayers were also included as comparators.

2013-12-01 | E-GEOD-38517 | biostudies-arrayexpress

Normal Oral Transcriptome

Project description:Three SAGE libraries brushed from the surface of the tongue and three SAGE libraries extracted from oral biopsies define the normal oral transcriptome. Keywords: SAGE, normal oral Six SAGE libraries isolated from the oral cavity were used to define the oral transcriptome.

2008-11-21 | E-GEOD-8127 | biostudies-arrayexpress

Normal Oral Transcriptome

2008-11-22 | GSE8127 | GEO