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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of wild-type and Rb-/- prostate epithelial cell lines under untreated and serum-free conditions.

ABSTRACT: Comparison of control wild-type and Rb-/- prostate epithelial cell lines under untreated and serum-free conditions.

ORGANISM(S): Mus musculus

SUBMITTER: Michael Thomas McCabe

PROVIDER: E-GEOD-934 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Disruption of Rb/E2F pathway results in increased cyclooxygenase-2 expression and activity in prostate epithelial cells.

Davis Joanne N JN McCabe Michael T MT Hayward Simon W SW Park John M JM Day Mark L ML

Cancer research 20050501 9

The loss of the retinoblastoma tumor suppressor gene (RB) is common in many human cancers, including prostate. We previously reported that engineered deletion of RB in prostate epithelial cells results in sustained cell growth in serum-free media, a predisposition to develop hyperplasia and dysplasia in prostate tissue recombinant grafts, and sensitization to hormonal carcinogenesis. Examining the molecular consequence of RB loss in this system, we show that cyclooxygenase-2 (COX-2) is significa ...[more]

PMID: 15867358

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