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Expression data from healthy controls and early stage CRC patient's tumor

ABSTRACT: Metastasis is the major cause of cancer mortality. Up to 25% of early stage sporadic colorectal cancer (CRC) patients succumb to metastasis after curative surgery. We used microarrays to detail gene expression and identified a metastasis-prone signature for early stage CRC. Keywords: RNA expression Tumors from age- and ethnicity-matched 70 patients and biopsies from 12 healthy controls were used. We aimed to find a metastasis-prone signature for early stage CRC by genome-wide expression profiling of age- and ethnicity-matched patients and healthy controls using the Affymetrix U133 Plus 2 array.

ORGANISM(S): Homo sapiens

SUBMITTER: Yi Hong

PROVIDER: E-GEOD-9348 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A 'metastasis-prone' signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics.

Hong Yi Y Downey Thomas T Eu Kong Weng KW Koh Poh Koon PK Cheah Peh Yean PY

Clinical & experimental metastasis 20100209 2

Metastasis is the major cause of cancer mortality. We aimed to find a metastasis-prone signature for early stage mismatch-repair proficient sporadic colorectal cancer (CRC) patients for better prognosis and informed use of adjuvant chemotherapy. The genome-wide expression profiles of 82 age-, ethnicity- and tissue-matched patients and healthy controls were analyzed using the Affymetrix U133 Plus 2 array. Metastasis-negative patients have 5 years or more of follow-up. A 10 x 10 two-level nested c ...[more]

PMID: 20143136

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Expression data from healthy controls and early stage CRC patient's tumor

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Homo sapiens

Project description:Expression data from early stage CRC patients' tumors [Agilent]

| PRJNA323568 | ENA

Homo sapiens

Project description:Expression data from early stage CRC patients' tumors [Affymetrix]

| PRJNA323569 | ENA