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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Arabidopsis csn3-1, csn4-1 and csn5 (csn5a-2 csn5b) COP9 signalosome (csn) mutant analysis

ABSTRACT: Transcript profiling analysis of csn3-1, csn4-1 and csn5 (csn5a-2 csn5b) light grown and dark grown mutant seedlings compared to light grown and dark grown wild type using Arabidopsis ATH1 GeneChip array Experiment Overall Design: We compare eight samples of 7 day-old light grown or dark grown csn3-1, csn4-1, and csn5 (csn5a-2 csn5b) mutant seedlings and light grown and dark grown wild type seedlings (3 independent biological replicates each).

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Claus Schwechheimer

PROVIDER: E-GEOD-9728 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.

Dohmann Esther M N EM Levesque Mitchell P MP De Veylder Lieven L Reichardt Ilka I Jürgens Gerd G Schmid Markus M Schwechheimer Claus C

Development (Cambridge, England) 20080423 11

The COP9 signalosome (CSN) is required for the full activity of cullin-RING E3 ubiquitin ligases (CRLs) in eukaryotes. CSN exerts its function on CRLs by removing the ubiquitin-related NEDD8 conjugate from the cullin subunit of CRLs. CSN seems, thereby, to control CRL disassembly or CRL subunit stability. In Arabidopsis thaliana, loss of CSN function leads to constitutive photomorphogenic (cop) seedling development and a post-germination growth arrest. The underlying molecular cause of this grow ...[more]

PMID: 18434413

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