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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human left ventricular apex samples

ABSTRACT: 19 paired human left ventricular apex samples were harvested at the time of implant of a left ventricular assist device (PRE) and at the time of explant (POST). The cohort included patients that were clinically classified as ischemic (I) showing evidence of coronary artery disease, non-ischemic (N) no evidence of coronary artery disease or acute Myocardial infarction (IM) myocardial infarction within 10 days of the implant. Tissue was processed and hybridized to the Affymetrix HG-U133A chip.

ORGANISM(S): Homo sapiens

DISEASE(S): ischemic

SUBMITTER: Grindle Suzanne

PROVIDER: E-GEOD-974 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks.

Hall Jennifer L JL Grindle Suzanne S Han Xinqiang X Fermin David D Park Soon S Chen Yingjie Y Bache Robert J RJ Mariash Ami A Guan Zhanjun Z Ormaza Sofia S Thompson Jeanne J Graziano Judith J de Sam Lazaro Shireen E SE Pan Shuchong S Simari Robert D RD Miller Leslie W LW

Physiological genomics 20040519 3

Mechanical unloading of the heart with a left ventricular assist device (LVAD) significantly decreases mortality in patients with heart failure. Moreover, it provides a human model to define the critical regulatory genes governing myocardial remodeling in response to significant reductions in wall stress. Statistical analysis of a gene expression library of 19 paired human heart samples harvested at the time of LVAD implant and again at explant revealed a set of 22 genes that were downregulated ...[more]

PMID: 14872006

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Left ventricular apex samples

Project description:19 paired human left ventricular apex samples were harvested at the time of implant of a left ventricular assist device (PRE) and at the time of explant (POST). The cohort included patients that were clinically classified as "ischemic" (I) showing evidence of coronary artery disease, "non-ischemic" (N) no evidence of coronary artery disease or "acute Myocardial infarction" (IM) myocardial infarction within 10 days of the implant. Tissue was processed and hybridized to the Affymetrix HG-U133A chip. Keywords: other

2004-01-18 | GSE974 | GEO

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2012-04-30 | E-GEOD-35088 | biostudies-arrayexpress

An Association Between Gene Expression and Better Survival in Female Mice Following Myocardial Infarction

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2010-08-31 | E-GEOD-23294 | biostudies-arrayexpress

Transcriptional profiling of left ventricle and peripheral blood cells in rats with post-myocardial infarction

Project description:Myocardial infarction (MI) often results in left ventricular (LV) remodeling followed by heart failure (HF). It is of great clinical importance to understand the molecular mechanisms that trigger transition from compensated LV injury to HF and to identify relevant diagnostic biomarkers. In this study, we performed transcriptional profiling of LVs in rats with a wide range of experimentally induced infarct sizes and of peripheral blood mononuclear cells (PBMCs) in animals that developed HF. We used microarrays to investigate gene expression in the left ventricle (LV) accompanying myocardial infarction and concomitant heart failure (HF) in a well validated model of post-infarcted heart failure and to evaluate their reflection in peripheral blood mononuclear cells (PBMCs) Myocardial infarction (MI) was induced in male Wistar rats by ligation of the proximal left coronary artery. The sham-operated group (control group) was subjected to the same protocol, except that the suture was not tied around the proximal left coronary artery. Sham-operated rats (n=6) and rats with small (n=6), moderate (n=6), and large (n=5) MI size were included into the experiment two months after the operation. Then, left ventricules and blood samples were obtained for RNA extraction and hybridization on Affymetrix microarrays. Microarrays were used to compare the LV and PBMCs transcriptomes of control and experimental animals. The development of heart failure was estimated by echocardiography and catheterization.

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Expression data of Sham and post-MI myocardium from swine

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Change of gene expression in mouse heart after permanent occlusion of the left anterior descending artery

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Transcription profiling of human heart characterizing the progression of heart failure in patients with aortic valve stenosis

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Counteraction of myocardial ferritin heavy chain deficiency by heme oxygenase-1

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2022-07-11 | GSE207609 | GEO

Acute effects of liraglutides on gene expression in the hearts of mice with experimental myocardial infarction

Project description:Glucagon-like peptide-1 receptor (GLP-1R) agonists reduce the rates of major cardiovascular events, including myocardial infarction in people with type 2 diabetes, and decrease infarct size while preserving ventricular function in preclinical studies. Nevertheless, the precise cellular sites of GLP-1R expression that mediate the cardioprotective actions of GLP-1 in the setting of ischemic cardiac injury are uncertain. Here, cardiac gene expression profiles regulated by liraglutide were examined using RNA-Seq to interrogate mouse atria and both non-infarcted and non-infarcted ventricular tissue after acute coronary artery ligation.

2022-11-21 | GSE217736 | GEO

Expression data of Sham and post-MI myocardium from swine

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