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Transcription profiling of olfactory bulbs from GFAP transgenic mice and wild type mice.

ABSTRACT: Olfactory bulb transcript levels for GFAP transgenic mice compared to wildtype at 3wks and 4mos.

ORGANISM(S): Mus musculus

SUBMITTER: Tracy Hagemann

PROVIDER: E-GEOD-977 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction.

Hagemann Tracy L TL Gaeta Stephen A SA Smith Mark A MA Johnson Delinda A DA Johnson Jeffrey A JA Messing Albee A

Human molecular genetics 20050713 16

Alexander disease is a fatal neurodegenerative disorder resulting from missense mutations of the intermediate filament protein, GFAP. The pathological hallmark of this disease is the formation of cytoplasmic protein aggregates within astrocytes known as Rosenthal fibers. Transgenic mice engineered to over-express wild-type human GFAP develop an encephalopathy with identical aggregates, suggesting that elevated levels of GFAP in addition to mutant protein contribute to the pathogenesis of this di ...[more]

PMID: 16014634

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