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Transcription profiling of human U2OS osteosarcoma cell line infected with ad-HIC1 to perform HICI target identification

ABSTRACT: The tumor suppressor gene HIC1 (Hypermethylated in Cancer 1) is essential for mammalian development and is epigenetically silenced in many human tumors. Functionally, HIC1 is involved in a complex pathway regulating P53 tumor-suppression activity. HIC1 encodes a sequence-specific transcriptional repressor containing five KrÃ¼ppel-like C2H2 zinc fingers but only a few genes regulated by HIC1 have been reported, including SIRT1. Experiment Overall Design: We performed genome-wide expression profiling analyses to identify new HIC1 target genes, in U2OS human osteosarcoma cells infected with adenoviruses expressing either HIC1 or GFP as control.

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Hoffman

PROVIDER: E-GEOD-9854 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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U2OS ad-HIC1 target identification

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