Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Cell Culture
SUBMITTER: Robert Moulder
LAB HEAD: Professor Riitta Lahesmaa
PROVIDER: PXD039337 | Pride | 2023-10-16
REPOSITORIES: Pride
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Immunology letters 20231012
Transcriptional repressor, hypermethylated in cancer 1 (HIC1) participates in a range of important biological processes, such as tumor repression, immune suppression, embryonic development and epigenetic gene regulation. Further to these, we previously demonstrated that HIC1 provides a significant contribution to the function and development of regulatory T (Treg) cells. However, the mechanism by which it regulates these processes was not apparent. To address this question, we used affinity-puri ...[more]