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Transcription profiling from C. elegans ETC mutants vs. Wildtypes

ABSTRACT: Utilizing C. elegans as a model of mitochondrial dysfunction provides insight into cellular adaptations which occur as a consequence of genetic alterations causative of human disease. We characterized genome-wide expression profiles of hypomorphic C. ele; Our goal was to detect concordant changes among clusters of genes that comprise defined metabolic pathways utilizing gene set enrichment analysis. Experiment Overall Design: 3 biological replicates of each C. elegans strain were used as sources of total RNA combined for hybridization to a single Affymetrix whole-genome microarray. Comparison of the data was intended to reveal metabolic pathways downstream of the mutation.

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Marni Falk

PROVIDER: E-GEOD-9897 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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