Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Small RNA-sequencing of 452 lymphoblastoid cell lines from the 1000 Genomes


ABSTRACT: This RNA sequencing data set of 465 human lymphoblastoid cell line samples from the CEU, FIN, GBR, TSI and YRI populations from the 1000 Genomes sample collection was created by the Geuvadis consortium (www.geuvadis.org, http://www.geuvadis.org/web/geuvadis/our-rnaseq-project). The data is under embargo until the first publication by the investigators in early 2013. This accession contains small RNA sequencing data, and mRNA data from the same samples are available under accession E-GEUV-1.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Natalja Kurbatova 

PROVIDER: E-GEUV-2 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptome and genome sequencing uncovers functional variation in humans.

Lappalainen Tuuli T   Sammeth Michael M   Friedländer Marc R MR   't Hoen Peter A C PA   Monlong Jean J   Rivas Manuel A MA   Gonzàlez-Porta Mar M   Kurbatova Natalja N   Griebel Thasso T   Ferreira Pedro G PG   Barann Matthias M   Wieland Thomas T   Greger Liliana L   van Iterson Maarten M   Almlöf Jonas J   Ribeca Paolo P   Pulyakhina Irina I   Esser Daniela D   Giger Thomas T   Tikhonov Andrew A   Sultan Marc M   Bertier Gabrielle G   MacArthur Daniel G DG   Lek Monkol M   Lizano Esther E   Buermans Henk P J HP   Padioleau Ismael I   Schwarzmayr Thomas T   Karlberg Olof O   Ongen Halit H   Kilpinen Helena H   Beltran Sergi S   Gut Marta M   Kahlem Katja K   Amstislavskiy Vyacheslav V   Stegle Oliver O   Pirinen Matti M   Montgomery Stephen B SB   Donnelly Peter P   McCarthy Mark I MI   Flicek Paul P   Strom Tim M TM   Lehrach Hans H   Schreiber Stefan S   Sudbrak Ralf R   Carracedo Angel A   Antonarakis Stylianos E SE   Häsler Robert R   Syvänen Ann-Christine AC   van Ommen Gert-Jan GJ   Brazma Alvis A   Meitinger Thomas T   Rosenstiel Philip P   Guigó Roderic R   Gut Ivo G IG   Estivill Xavier X   Dermitzakis Emmanouil T ET  

Nature 20130915 7468


Genome sequencing projects are discovering millions of genetic variants in humans, and interpretation of their functional effects is essential for understanding the genetic basis of variation in human traits. Here we report sequencing and deep analysis of messenger RNA and microRNA from lymphoblastoid cell lines of 462 individuals from the 1000 Genomes Project--the first uniformly processed high-throughput RNA-sequencing data from multiple human populations with high-quality genome sequences. We  ...[more]

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