Transcription profiling of Strongyloides ratti life-history traits
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ABSTRACT: Strongyloides ratti is a parasitic nematode of rats and a laboratory model for nematode infection more generally. Selected lines were generated over the course of 20 - 30 generations such that eggs were harvested either at the beginning or towards the end of an infection, termed 'fast' and 'slow' lines, respectively. Phenotypic differences in these lines in their fecundity and response to host immunity were observed. The gene expression response of these lines in both permissive and restrictive immune environments were assayed using cDNA microarrays. Large numbers of responding genes were found (but with modest fold changes) and clusters of co-expressed genes identified. Genes exhibiting female-biased expression responded to host immunity, consistent with increased investment into transmission in restrictive immune environments.
ORGANISM(S): Strongyloides ratti
SUBMITTER: unknown unknown
PROVIDER: E-MAXD-54 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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