Dataset Information

Proteomic profile of two different cerebral hypoxic models treated with antioxidant melatonin and nitric oxide donors

ABSTRACT: In the present work we analyse the proteomic profile of two models of cerebral hypoxia with different severity as well as their response after treatment with the antioxidant melatonin and the nitric oxide-donor isosorbide mononitrate (ISMN).

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

DISEASE(S): Brain Hypoxia-ischemia

SUBMITTER: Santos Blanco

LAB HEAD: Maria Angeles Peinado

PROVIDER: PXD004091 | Pride | 2017-07-17

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	G1_Santos_TMTGrupo1_07112013.mzML	Mzml
	G1_Santos_TMTGrupo1_07112013.raw	Raw
	G2_Santos_TMTGrupo2_18102013_131112100714.mzML	Mzml
	G2_Santos_TMTGrupo2_18102013_131112100714.raw	Raw
	Protocol.Identification.txt	Txt

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Publications

Comparative proteomic study of early hypoxic response in the cerebral cortex of rats submitted to two different hypoxic models.

Ovelleiro David D Blanco Santos S Hernández Raquel R Peinado María Ángeles MÁ

Proteomics. Clinical applications 20170822 11-12

<h4>Purpose</h4>The present study analyses and compares the cortical brain proteomic profiles of two different models of cerebral hypoxic insult in rats (HH: hypobaric hypoxia and HHI: ischemia followed by hypobaric hypoxia) in an attempt to describe the alterations of the early molecular hypoxic adaptive response underlying each one.<h4>Experimental design</h4>A quantitative proteomic profile of left-brain cortices of rats under HH, HHI, and control conditions was determined using isobaric labe ...[more]

PMID: 28697276

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