Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling of adult male zebrafish exposed to 17-beta estradiol (E2) for 0, 1, 4. 12 and 24 hours


ABSTRACT: Microarrays displaying zebrafish miRNAs specific probes were hybridized using RNA samples originating from whole body homogenates of male zebrafish exposed to 17-beta estradiol (E2) for 0, 1, 4. 12 and 24 hours. 0 hr fish No. 40, 41, 42. 1hr fish No. 8, 10, 11. 4hr fish No. 19, 20, 23. 12hr fish No. 24, 25, 26. 24hr fish No. 29, 31, 32.

The hybridizations used in these experiments: Chip 1: 10-42, Chip 2: 40-8, Chip 3: 41-11, Chip 4: 42-19, Chip 5: 20-40, Chip 6: 23-41, Chip 7: 25-42, Chip 8: 40-24, Chip 9: 41-26, Chip 10: 42-29, Chip 11: 31-40, Chip 12: 32-41

INSTRUMENT(S): GenePix 4000B [Axon Instruments]

ORGANISM(S): Danio rerio

SUBMITTER: Amit Cohen 

PROVIDER: E-MEXP-1147 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Alterations in micro-ribonucleic acid expression profiles reveal a novel pathway for estrogen regulation.

Cohen Amit A   Shmoish Michael M   Levi Liraz L   Cheruti Uta U   Levavi-Sivan Berta B   Lubzens Esther E  

Endocrinology 20071220 4


Estrogens are steroid hormones that have been implicated in a variety of cellular and physiological processes in the development of diseases such as cancer and are also known to be associated with the effects of endocrine disrupting chemicals. Here we show that 17beta-estradiol (E(2)) alters microRNA (miRNA) expression profiles in the adult zebrafish (Danio rerio). An association between E(2) and the expression of 25 miRNAs was found 12 h after treatment. Among the most up-regulated miRNAs were  ...[more]

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