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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling of liver from vitellogenic and non-vitellogenic zebrafish females

ABSTRACT: Liver samples were collected from zebrafish females (3 months old). Vitellogenic females were maintained under conditions of 14 h light: 10 h dark. Non-vitellogenic females were obtained by exposing females to 6 h light/18 h dark regime.

ORGANISM(S): Danio rerio

SUBMITTER: Amit Cohen

PROVIDER: E-MEXP-1572 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Estrogen regulation of microRNAs, target genes, and microRNA expression associated with vitellogenesis in the zebrafish.

Cohen Amit A Smith Yoav Y

Zebrafish 20130615 5

Estrogen is a steroid hormone that has been implicated in a variety of cellular and physiological processes and in the development of diseases such as cancer. Here we show a remarkable widespread microRNA (miRNA) downregulation in the zebrafish (Danio rerio) liver following 17β-estradiol (E2) treatment. This unique miRNA expression signature in the fish liver was further supported by a combination of computational predictions with gene expression microarray data, showing a significant bias towar ...[more]

PMID: 23767875

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