Transcription profiling of mouse Y1 adrenocortical cells treated with trichostatin
Ontology highlight
ABSTRACT:
INSTRUMENT(S): GenePix 4000B [Axon Instruments]
ORGANISM(S): Mus musculus
SUBMITTER: Bon-chu Chung
PROVIDER: E-MEXP-1197 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of steroidogenic factor 1 (NR5A1).
Chen Wei-Yi WY Weng Jui-Hsia JH Huang Chen-Che CC Chung Bon-Chu BC
Molecular and cellular biology 20070820 20
Histone deacetylase (HDAC) inhibitors such as trichostatin A and valproic acid modulate transcription of many genes by inhibiting the activities of HDACs, resulting in the remodeling of chromatin. Yet this effect is not universal for all genes. Here we show that HDAC inhibitors suppressed the expression of steroidogenic gene CYP11A1 and decreased steroid secretion by increasing the ubiquitination and degradation of SF-1, a factor important for the transcription of all steroidogenic genes. This w ...[more]
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