Transcription profiling of human endothelial cells and pericytes from endometriotic nodules and control endometrial and myometrial tissue to identify specific markers of rectovaginal endometriotic nodule vasculature

ABSTRACT: To identify specific markers of rectovaginal endometriotic nodule vasculature, highly enriched preparations of vascular endothelial cells and pericytes were obtained from endometriotic nodules and control endometrial and myometrial tissue by laser capture microdissection (LCM), and gene expression profiles were screened by microarray analysis. Of the 18,400 transcripts on the arrays, 734 were significantly overexpressed in vessels from fibromuscular tissue and 923 in vessels from stromal tissue of endometriotic nodules, compared to vessels dissected from control tissues. The most frequently expressed transcripts included known endothelial cell-associated genes, as well as transcripts with little or no previous association with vascular cells. The higher expression in blood vessels was furt

ORGANISM(S): Homo sapiens

SUBMITTER: Anne Van Langendonckt 

PROVIDER: E-MEXP-1251 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress