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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional profiling of monocytes of bipolar patients and controls

ABSTRACT: Bipolar disorder (BD) is a psychiatric disorder in which the core feature is pathological disturbance in mood ranging from extreme elation (mania) to severe depression. Study has shown an aberrant pro-inflammatory status of monocytes/macrophages in mood disorders. Therefore, this study aimed at studying the monocyte compartment in Bipolar Disorder, by transcription profiling of CD14+ monocytes in patients and controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Roos Padmos

PROVIDER: E-MEXP-1275 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes.

Padmos Roos C RC Hillegers Manon H J MH Knijff Esther M EM Vonk Ronald R Bouvy Anne A Staal Frank J T FJ de Ridder Dick D Kupka Ralph W RW Nolen Willem A WA Drexhage Hemmo A HA

Archives of general psychiatry 20080401 4

<h4>Context</h4>Mood disturbances are associated with an activated inflammatory response system.<h4>Objective</h4>To identify a discriminating and coherent expression pattern of proinflammatory genes in monocytes of patients with bipolar disorder.<h4>Design</h4>A quantitative polymerase chain reaction (Q-PCR) case-control gene expression study on purified monocytes of bipolar patients, the offspring of bipolar patients, and healthy control participants after having selected 22 discriminating inf ...[more]

PMID: 18391128

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